… Most drug discovery efforts fail because enzyme-inhibitory activities (IC 50 values) cannot be
translated to whole cell inhibition (MIC … The cells were treated with various concentrations of …

… gene expression and protein synthesis in the infected host cell, which … drug that functions
by inhibiting the HIV aspartyl protease—was shown to prevent lytic egress and the cell-to-cell …

… for GTP catalyzed by eIF2B which prevents the formation of the ternary … PKR regulates global
protein synthesis in response to … and hence it is an important drug target. However, specific …

… drugs that are the mainstay of modern antimicrobial drug … that deregulated protein synthesis
in cancer cells represents a … global inhibitory effects on translation exerted in cells treated …

… protein was obtained from Roche Life Science (Stockholm, Sweden). LPS, ATP, and 2-aminopurine
(… activation, we treated iBMDMs and PMs with 2-AP, a potent PKR inhibitor (20). 2-AP …

… For example, by binding tightly to PKR, adenovirus VA RNA … role in the initiation of protein
synthesis. The overall amounts … mRNA in the intact cell is blocked by 2-aminopurine or by the …

… of host-cell protein synthesis, and enhancement of virus DNA … adenovirus replication in HepG2
cells, and 2-Aminopurine … and serum components and to prevent sequestration by MPS in …

… to proteostasis defects by tuning protein synthesis. The ISR is … developed drug-like
small-molecule ISR inhibitor that is … (156) and can be prevented by ISRIB in a human cellular three-…

… In particular, the combination of 2-aminopurine and zebularine… -deleted adenovirus in
hepatocellular carcinoma cells (27), … ZEB-treated mismatch repair (MMR)-deficient cells compared …

… A significant example is represented by 2Aminopurine (4) in … , is a PknB inhibitor capable of
preventing mycobacterial cell … inhibitor of PknB, suggesting a strategy for drug design based …